Syntheses and glycosidase inhibiting activities of nagstatin analogs.

Synthesis and glycosidase inhibitory activities of nagstatin triazole analogs.

Recently, we have enatiospeciflcally synthesized nagstatin (1) and its analogs (for example, 2) having different configurations and functionalities and clarified the structure-activity relationships2 ~ 4). Herein, we describe the synthesis of the triazole analogs (3 and 4) having a triazole ring in place of an imidazole ring, and evaluate their glycosidase inhibitory activities to better unders...

Syntheses and enzyme inhibiting activities of cyclophellitol analogs.

SYNTHESIS OF PURINE ACYCLONUCLEOSIDES HAVING PRONOUNCED ANTIVIRAL ACTIVITY

The synthesis of a series of purine analogues of the acyclonucleoside compound 14 (acyclovir) is described. Compounds in this series have been shown to have pronounced activity against herpes virus-type l(HSV-1). The anti-viral activities of other analogs whose syntheses were recently reported [1] by us are also described

Syntheses of the potent inhibitors of neuraminidase, N-(1,2-dihydroxypropyl) derivatives of siastatin B and its 4-deoxy analogs.

Polyand multifunctional piperidines isolated from microorganisms and plants are powerful and specific glycosidase inhibitors, and they have the potential to produce a number of kinds of beneficial therapeutic effects such as antihyperglycemic, antiviral and anticancer activity, etc. l) A multifunctional piperidine, siastatin B (1) which was isolated as an inhibitor of neuraminidase by H. Umezaw...

RNA N - glycosidase and anti - tumor activities

1. Abstract 2. Introduction 3. Material and methods 3.1. Cloning and sequencing of TYchi gene 3.2. Southern and northern blot hybridization 3.3. Expression and Purification of Recombinant TYchi 3.4. Chitinase enzymic assay of TYchi 3.5. Assay for RNA N-glycosidase activity 3.6. Assay for cell-free translation-inhibiting activity 3.7. Assay for cytotoxic activity on human tumor cells 3.8. Modeli...